This family includes the vertebrate proteins MAP2, MAP4 and Tau,as well as other animal homologs. MAP4 is present in manytissues but is usually absent from neurons; MAP2 and Tau aremainly neuronal. Members of this family have the ability to bindto and stabilise microtubules. As a result, they are involved inneuronal migration, supporting dendrite elongation, andregulating microtubules during mitotic metaphase. Note that Tau(Swiss:P10636) is involved in neurofibrillary tangle formationin Alzheimer's disease and some other dementias. This familyfeatures a C-terminal microtubule binding repeat that contains aconserved KXGS motif [1]. Tau and MAP protein, tubulin-binding repeat Tubulin-binding